Lab Papers
Romero LO, Caires R, Victor AK, Ramirez J, Sierra-Valdez FJ, Walsh P, Truong V, Lee J, Mayor U, Reiter LT, Vásquez V*, Cordero-Morales JF*. Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome. Nature Communications 14, 1167 (2023). https://doi.org/10.1038/s41467-023-36818-0. *Corresponding authors.
Goodman MB, Haswell ES, Vásquez V. Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction. 2023. Journal of General Physiology. 155(3):e202213248. doi: 10.1085/jgp.202213248.
Ma S, Dubin A.E., Romero L.O., Loud M., Salazar A., Chu, S., Klier, N., Masri S., Zhang, Y., Wang Y, Chesler A.T., Wilkinson K., Vásquez V, Marshall K.S., Patapoutian A. 2023. Excessive mechanotransduction in sensory neurons causes joint contractures. Science. 379 (6628): 201-206. doi: 10.1126/science.add3598. [Covered by “Perspective” in Science].
Caires R, Garrud T.A.C., Romero L.O., Fernández-Peña C, Vásquez V, Jaggar J.H., Cordero-Morales J.F. 2022. Genetic- and diet-induced w-3 fatty acid enrichment enhances TRPV4-mediated vasodilation in mice. Cell Reports. 40, September 6. https://doi.org/10.1016/j.celrep.2022.111306
Meena AS, Shukla PK, Bell B, Giorgianni F, Caires R, Fernández-Peña C, Beranova S, Aihara E, Montrose MH, Chaib M, Makowski L, Neeli I, Radic MZ, Vásquez V, Jaggar JH, Cordero-Morales JF*, Rao R*. 2022. TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response. Cell Reports. Jun 14;39(11):110937. doi: 10.1016/j.celrep.2022.110937. PMID: 35705057.*Corresponding authors.
Millet JRM, Romero LO, Lee J, Bell B, Vásquez V. C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation. 2022. Journal of General Physiology. 154(1). doi: 10.1085/jgp.202112960. [Covered by "Research News" in the Journal of General Physiology] .
Zhang S, Romero LO, Deng S, Wang J, Li Y, Yang L, Hamilton DJ, Miller DD, Liao F-F, Cordero-Morales JF*, Wu Z*, and Li W*. 2021. Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity. ACS Medicinal Chemistry Letters. Publication Date: March 5, 2021. *Corresponding authors.
Caires R, Bell B, Lee J, Romero LO, Vásquez V*, Cordero-Morales JF*. 2021. Deficiency of inositol monophosphatase activity decreases phosphoinositide lipids and enhances TRPV1 function in vivo. Journal of Neuroscience. 41(3):408–423. *Corresponding authors.
Romero LO, Caires R, Nickolls A, Chesler AT*, Cordero-Morales JF*, and Vásquez V*. 2020. A dietary fatty acid counteracts neuronal mechanical sensitization. Nature Communications 11, 2997 (2020). https://doi.org/10.1038/s41467-020-16816-2. *Corresponding authors.
Vásquez V. 2020. Using C. elegans to study the effects of toxins in sensory ion channels in vivo. Methods in Molecular Biology. 2020;2068:225-238. doi: 10.1007/978-1-4939-9845-6_12.
Nikolaev YA, Cox CD, Ridone P, Rohde PR, Cordero-Morales JF, Vásquez V, Laver DR, Martinac B. 2019. Mammalian TRP ion channels are insensitive to membrane stretch. Journal of Cell Science. Nov 13;. doi: 10.1242/jcs.238360. [Epub ahead of print] PubMed PMID: 31722978.
Romero LO, Massey AE, Mata-Daboin AD, Sierra-Valdez FJ, Chauhan SC, Cordero-Morales JF, and Vásquez V*. 2019. Dietary fatty acids fine-tune Piezo1 mechanical response. Nature Communications. Mar 13;10(1):1200. *Corresponding author.
Geron M, Kumar R, Zhou W, Faraldo-Gómez JD, Vásquez V*, and Priel A*. 2018. TRPV1 pore turret dictates distinct DkTx and capsaicin gating. Proceedings of the National Academy of Sciences. Dec 11;115(50):E11837-E11846. doi: 10.1073/pnas.1809662115 *Corresponding authors.
Li D, Zou XY, El-Ayachi I, Romero LO, Yu Z, Iglesias-Linares A, Cordero-Morales JF, Huang GT. 2018. Human Dental Pulp Stem Cells and Gingival Mesenchymal Stem Cells Display Action Potential Capacity In Vitro after Neuronogenic Differentiation. Stem Cell Reviews and Reports. Oct 15. doi: 10.1007/s12015-018-9854-5.
Sierra-Valdez F, Azumaya CM, Romero LO, Nakagawa T*, Cordero-Morales JF*. 2018. Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating. Journal of Biological Chemistry. *Corresponding authors.
Sierra-Valdez F, Stein R, Velissety P, Vásquez V, Cordero-Morales JF*. 2018. Purification and Reconstitution of TRPV1 for Spectroscopic Analysis. Journal of Visualized Experiments (137), e57796, doi:10.3791/57796. *Corresponding author.
Azumaya CM, Sierra-Valdez F, Cordero-Morales JF*, Nakagawa T*. 2018. Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6). Journal of Biological Chemistry. *Corresponding authors.
Cordero-Morales, JF and Vásquez, V*. 2018. How lipids contribute to ion channel function, a fat perspective on direct and indirect interactions. Current Opinion in Structural Biology, 51:1–7.*Corresponding author.
Caires R, Sierra-Valdez F, Millet JRM, Herwig JD, Roan E, Vásquez V*, Cordero-Morales JF*. 2017. Omega-3 Fatty Acids Modulate TRPV4 Function Through Plasma Membrane Remodeling. Cell Reports, 21: 246-258. *Corresponding authors.
Velisetty P, Stein RA, Sierra-Valdez F, Vásquez V, Cordero-Morales JF*. 2017. Expression and Purification of the Pain Receptor TRPV1 for Spectroscopic Analysis. Scientific Reports. 7: 9861. *Corresponding author.
Goodman MB, Haswell ES, Vásquez V. Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction. 2023. Journal of General Physiology. 155(3):e202213248. doi: 10.1085/jgp.202213248.
Ma S, Dubin A.E., Romero L.O., Loud M., Salazar A., Chu, S., Klier, N., Masri S., Zhang, Y., Wang Y, Chesler A.T., Wilkinson K., Vásquez V, Marshall K.S., Patapoutian A. 2023. Excessive mechanotransduction in sensory neurons causes joint contractures. Science. 379 (6628): 201-206. doi: 10.1126/science.add3598. [Covered by “Perspective” in Science].
Caires R, Garrud T.A.C., Romero L.O., Fernández-Peña C, Vásquez V, Jaggar J.H., Cordero-Morales J.F. 2022. Genetic- and diet-induced w-3 fatty acid enrichment enhances TRPV4-mediated vasodilation in mice. Cell Reports. 40, September 6. https://doi.org/10.1016/j.celrep.2022.111306
Meena AS, Shukla PK, Bell B, Giorgianni F, Caires R, Fernández-Peña C, Beranova S, Aihara E, Montrose MH, Chaib M, Makowski L, Neeli I, Radic MZ, Vásquez V, Jaggar JH, Cordero-Morales JF*, Rao R*. 2022. TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response. Cell Reports. Jun 14;39(11):110937. doi: 10.1016/j.celrep.2022.110937. PMID: 35705057.*Corresponding authors.
Millet JRM, Romero LO, Lee J, Bell B, Vásquez V. C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation. 2022. Journal of General Physiology. 154(1). doi: 10.1085/jgp.202112960. [Covered by "Research News" in the Journal of General Physiology] .
Zhang S, Romero LO, Deng S, Wang J, Li Y, Yang L, Hamilton DJ, Miller DD, Liao F-F, Cordero-Morales JF*, Wu Z*, and Li W*. 2021. Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity. ACS Medicinal Chemistry Letters. Publication Date: March 5, 2021. *Corresponding authors.
Caires R, Bell B, Lee J, Romero LO, Vásquez V*, Cordero-Morales JF*. 2021. Deficiency of inositol monophosphatase activity decreases phosphoinositide lipids and enhances TRPV1 function in vivo. Journal of Neuroscience. 41(3):408–423. *Corresponding authors.
Romero LO, Caires R, Nickolls A, Chesler AT*, Cordero-Morales JF*, and Vásquez V*. 2020. A dietary fatty acid counteracts neuronal mechanical sensitization. Nature Communications 11, 2997 (2020). https://doi.org/10.1038/s41467-020-16816-2. *Corresponding authors.
Vásquez V. 2020. Using C. elegans to study the effects of toxins in sensory ion channels in vivo. Methods in Molecular Biology. 2020;2068:225-238. doi: 10.1007/978-1-4939-9845-6_12.
Nikolaev YA, Cox CD, Ridone P, Rohde PR, Cordero-Morales JF, Vásquez V, Laver DR, Martinac B. 2019. Mammalian TRP ion channels are insensitive to membrane stretch. Journal of Cell Science. Nov 13;. doi: 10.1242/jcs.238360. [Epub ahead of print] PubMed PMID: 31722978.
Romero LO, Massey AE, Mata-Daboin AD, Sierra-Valdez FJ, Chauhan SC, Cordero-Morales JF, and Vásquez V*. 2019. Dietary fatty acids fine-tune Piezo1 mechanical response. Nature Communications. Mar 13;10(1):1200. *Corresponding author.
Geron M, Kumar R, Zhou W, Faraldo-Gómez JD, Vásquez V*, and Priel A*. 2018. TRPV1 pore turret dictates distinct DkTx and capsaicin gating. Proceedings of the National Academy of Sciences. Dec 11;115(50):E11837-E11846. doi: 10.1073/pnas.1809662115 *Corresponding authors.
Li D, Zou XY, El-Ayachi I, Romero LO, Yu Z, Iglesias-Linares A, Cordero-Morales JF, Huang GT. 2018. Human Dental Pulp Stem Cells and Gingival Mesenchymal Stem Cells Display Action Potential Capacity In Vitro after Neuronogenic Differentiation. Stem Cell Reviews and Reports. Oct 15. doi: 10.1007/s12015-018-9854-5.
Sierra-Valdez F, Azumaya CM, Romero LO, Nakagawa T*, Cordero-Morales JF*. 2018. Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating. Journal of Biological Chemistry. *Corresponding authors.
Sierra-Valdez F, Stein R, Velissety P, Vásquez V, Cordero-Morales JF*. 2018. Purification and Reconstitution of TRPV1 for Spectroscopic Analysis. Journal of Visualized Experiments (137), e57796, doi:10.3791/57796. *Corresponding author.
Azumaya CM, Sierra-Valdez F, Cordero-Morales JF*, Nakagawa T*. 2018. Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6). Journal of Biological Chemistry. *Corresponding authors.
Cordero-Morales, JF and Vásquez, V*. 2018. How lipids contribute to ion channel function, a fat perspective on direct and indirect interactions. Current Opinion in Structural Biology, 51:1–7.*Corresponding author.
Caires R, Sierra-Valdez F, Millet JRM, Herwig JD, Roan E, Vásquez V*, Cordero-Morales JF*. 2017. Omega-3 Fatty Acids Modulate TRPV4 Function Through Plasma Membrane Remodeling. Cell Reports, 21: 246-258. *Corresponding authors.
Velisetty P, Stein RA, Sierra-Valdez F, Vásquez V, Cordero-Morales JF*. 2017. Expression and Purification of the Pain Receptor TRPV1 for Spectroscopic Analysis. Scientific Reports. 7: 9861. *Corresponding author.
Julio F. Cordero-Morales, Ph.D.Cao E, Cordero-Morales JF, Liu B, Qin F, and Julius D. 2013. TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron 77:667-679.
Raghuraman H, Cordero-Morales JF, Jogini V, Pan AC, Kollewe A, Roux B and Perozo P. 2012. Mechanism of Cd2+-coordination during slow inactivation in potassium channels. Structure. 20:1-11. Cordero-Morales JF*, Gracheva EO* and Julius D. 2011. Cytoplasmic Ankyrin Repeat Domains of TRPA1 Dictate Sensitivity to Thermal and Chemical Stimuli. Proceedings of the National Academy of Sciences of the United States of America 108:E1184–E1191. *These authors equally contributed to this work. Ferrer-Villada T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E and Tristani-Firouzi M. 2011. Molecular coupling in the hERG K+ channel inactivation pathway. The Journal of Biological Chemistry . 286:39091-9. Cordero-Morales JF, Jogini V, Chakrapani S, and Perozo E. 2011. A multipoint hydrogen bond network underlying KcsA C-type inactivation. Biophysical Journal. 100:2387-2393. Chakrapani S*, Cordero-Morales JF*, Jogini V, Pan A, Cortes DM, Roux B and Perozo, E. 2011. On the structural basis of modal gating behavior in K+ channels. Nature Structural and Molecular Biology. 18:67-75. * These author equally contributed to this work. Gracheva EO*, Cordero-Morales JF*, González-Carcacía JA, Ingolia NT, Aranguren CI, Manno C, Weissman JS, and Julius D. 2011. Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature. 476:88-91. * These author equally contributed to this work. 
Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, and Julius D. 2010. Molecular Basis of Infrared Detection by Snakes. Nature. 464:1006-1011.
Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DH, Dalmas O, Cordero-Morales JF, Chakrapani S, Roux B and Perozo E. 2010. Structural Basis for the Coupling between Activation and Inactivation Gate in Potassium Channels. Nature. 466:272-276. Vásquez V., Sotomayor M., Cordero-Morales JF, Schulten K., and Perozo E. 2008. A Structural Mechanism for MscS gating in Lipid Bilayers. Science. 321:1210-1214. Cordero-Morales JF, Jogini V., Lewis A., Vásquez V., Cortes D.M, Roux B., and Perozo E. 2007. Molecular driving forces determining potassium channel slow inactivation. Nature Structural and Molecular Biology. 14: 1062-1069. Chakrapani S., Cordero-Morales JF, and Perozo E. 2007. A quantitative description of KcsA gating. Macroscopic current I. Journal of General Physiology. 130: 465-478. Chakrapani S., Cordero-Morales JF, and Perozo E. 2007. A quantitative description of KcsA gating. Single channel current II. Journal of General Physiology. 130: 479-496. Cordero-Morales J.F., Cuello L., Zhao Y., Jogini V., Cortes D.M., Roux B., and Perozo E. 2006. Molecular determinants of gating at the potassium channel selectivity filter. Nature Structural and Molecular Biology. 13: 311-318. 
Cordero-Morales J.F., Cuello L., and Perozo E. 2006. Voltage-dependent gating at the potassium channel selectivity filter. Nature Structural and Molecular Biology. 13: 319-321.
Blunck R., Cordero-Morales J.F., Cuello L., Perozo E., and Bezanilla F. 2006. Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. Journal of General Physiology. 128: 569-581. Cordero J.F., Rodriguez P., and Romero P. 2004. Differences in intramembrane particles distribution in young and old human erythrocytes. Cell Biology International. 28: 423-31. Cordero J.F. and Romero P. 2002. Caffeine activates mechanosensitive Ca2+ channels in human red cells. Cell Calcium. 31: 189-200. |
Valeria Vásquez, Ph.D.
Vásquez V, Scherrer G, and Goodman MB. 2014. Sensory biology: It takes Piezo2 to tango. Current Biology. 24(12): R566-R569.
Vásquez V, Krieg M, Lockhead D, and Goodman MB. 2014. Phospholipids that Contain Polyunsaturated Fatty Acids Enhance Neuronal Cell Mechanics and Touch Sensation. Cell Reports 6: 1-11. Vásquez V. 2013. MscS Inactivation: an Exception rather than the Rule. An Extremophilic MscS Reveals Diversity within the Family. Biophysical Journal 104(7): 1391-1393. Martinac B, Rohde PR, Battle AR, Petrov E, Pal P, Foo AF, Vásquez V, Huynh T, and Kloda A. 2010. Studying Mechanosensitive Ion Channels using Liposomes. In: Methods in Molecular Biology. Liposomes. 606 (31-53). V. Weissig, ed. Humana Press, Springer Publishing Group (USA). Vásquez V and Perozo E. 2009. A Channel with a Twist. Nature. 461(7260): 47-49. Uysal S, Vásquez V, Terechko V, Esaki K, Fellouse FA, Sidhu SS, Koide S, Perozo E, and Kossiakoff A. 2009. The Crystal Structure of Full-Length KcsA in its Closed Conformation. Proceedings of the National Academy of Sciences of the United States of America. 106(16): 6644-6649. Vásquez V, Sotomayor M, Cordero-Morales JF, Schulten K, and Perozo E. 2008. A Structural Mechanism for MscS gating in Lipid Bilayers. Science. 321(5893): 1210-1214. Vásquez V, Sotomayor M, Cortes DM, Roux B, Schulten K, and Perozo E. 2008. Three-Dimensional Architecture of Membrane-Embedded MscS in the Closed Conformation. Journal of Molecular Biology. 378(1): 55-70. Cordero-Morales JF, Jogini V, Lewis A, Vásquez V, Cortes DM, Roux B, and Perozo E. 2007. Molecular Driving Forces Determining Potassium Channel Slow Inactivation. Nature Structural & Molecular Biology. 14(11): 1062-1069. Vásquez V, Cortes DM, Furukawa H, and Perozo E. 2007. An Optimized Purification and Reconstitution Method for the MscS Channel: Strategies for Spectroscopical Analysis. Biochemistry. 46(23): 6766-6773. Sotomayor M*, Vásquez V*, Perozo E, and Schulten K. 2007. Ion Conduction through MscS as determined by Electrophysiology and Simulation. Biophysical Journal. 92(3): 886-902. *These authors equally contributed to this work. Santana MA, Vásquez V, Matehus J, and Rangel-Aldao R. 2002. Linamarase Expression in Cassava Cultivars with Roots of Low- and High- Cyanide Content. Plant Physiology. 129(4): 1686-1694. |
